Localization of cell groups sensitive to parathyroid hormone and calcitonin in rat skeletal tissue

N Nagata, N Kimura, M Sasaki, K Nakane… - Biochimica et Biophysica …, 1976 - Elsevier
The level of cyclic AMP in various fractions of rat skeletal tissue was measured after in vitro
or in vivo administration of parathyroid hormone and calcitonin. Incubations of bone fractions
prepared from young (5 weeks of age) thyroparathyroidectomized rats revealed that both
parathyroid hormone and calcitonin increased the cyclic AMP level in fractions of epiphysis,
metaphysis and marrow cells. Cyclic AMP accumlation in incubated periosteum and
diaphysis were induced solely by parathyroid hormone. In in vivo experiments, the cyclic …
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